Treatments  > Biological > Medication > Typicals

Typicals

  • Chlorpromazine (Largactil, Thorazine),

  • Thioridazine (Mellaril),

  • Levomepromazine,

  • Perphenazine (Trilafon),

  • Trifluoperazine (Stelazine),

  • Haloperidol (Haldol, Serenace),

  • Fluphenazine (Prolixin),

  • Zuclopenthixol (Clopixol),

  • Flupentixol (Depixol),

  • Prochlorperazine

 

  • Main action on D2 receptor

 

  • Produce extrapyramidal side effects at clinically effective doses

 

 

Side effects related to receptor affinities:

 

  • Dopamine - movement disorders such as

- dystonia (rapid onset of muscle contraction)

- akathesia (subjective feeling of inner restlessness with resultant physical agitation)

- parkinsonism (bradykinesia, rigidity, postural instability and tremor)

- tardative dyskinesia (repetitive involuntary movements from longer term administration and can be irreversible)

- neuroleptic malignant syndrome

- hyperprolactinemia

 

  • Ach - dry mouth, blurred vision etc.

  • Alpha adrenergic - postural HTN, impotence etc

  • Histamine - sedation, weight gain

  • Serotonin - weight gain