Treatments > Biological > Medication > Typicals
Typicals
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Chlorpromazine (Largactil, Thorazine),
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Thioridazine (Mellaril),
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Levomepromazine,
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Perphenazine (Trilafon),
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Trifluoperazine (Stelazine),
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Haloperidol (Haldol, Serenace),
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Fluphenazine (Prolixin),
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Zuclopenthixol (Clopixol),
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Flupentixol (Depixol),
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Prochlorperazine
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Main action on D2 receptor
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Produce extrapyramidal side effects at clinically effective doses
Side effects related to receptor affinities:
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Dopamine - movement disorders such as
- dystonia (rapid onset of muscle contraction)
- akathesia (subjective feeling of inner restlessness with resultant physical agitation)
- parkinsonism (bradykinesia, rigidity, postural instability and tremor)
- tardative dyskinesia (repetitive involuntary movements from longer term administration and can be irreversible)
- neuroleptic malignant syndrome
- hyperprolactinemia
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Ach - dry mouth, blurred vision etc.
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Alpha adrenergic - postural HTN, impotence etc
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Histamine - sedation, weight gain
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Serotonin - weight gain