RevisePsych

Typicals

• Chlorpromazine (Largactil, Thorazine),

• Thioridazine (Mellaril),

• Levomepromazine,

• Perphenazine (Trilafon),

• Trifluoperazine (Stelazine),

• Haloperidol (Haldol, Serenace),

• Fluphenazine (Prolixin),

• Zuclopenthixol (Clopixol),

• Flupentixol (Depixol),

• Prochlorperazine

 

• Main action on D2 receptor

 

• Produce extrapyramidal side effects at clinically effective doses

 

 

Side effects related to receptor affinities:

 

• Dopamine - movement disorders such as

- dystonia (rapid onset of muscle contraction)

- akathesia (subjective feeling of inner restlessness with resultant physical agitation)

- parkinsonism (bradykinesia, rigidity, postural instability and tremor)

- tardative dyskinesia (repetitive involuntary movements from longer term administration and can be irreversible)

- neuroleptic malignant syndrome

- hyperprolactinemia

 

• Ach - dry mouth, blurred vision etc.

• Alpha adrenergic - postural HTN, impotence etc

• Histamine - sedation, weight gain

• Serotonin - weight gain