Treatments > Biological > Medication > Neuroleptic Malignant Syndrome (NMS)
Neuroleptic Malignant Syndrome (NMS)
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Idiosyncratic side effect primarily associated with antipsychotics
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Marked by
- muscular rigidity pyrexia,
- autonomic instability (unstable BP, tachycardia, increased sweating, increased salivation, urinary incontinence),
- decreased consciousness,
- increased creatinine kinase (CPK),
- leucocytosis,
- low serum iron
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Medical emergency that can lead to death.
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Treatment
- stop neuroleptic, treat hyperthermia aggressively.
- May need ICU.
- Dopamine agonists (dantrolene), benzodiazapines for agitation.
- Aggressive hydration with diuresis as myoglobin levels may result in renal failure.
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Early recognition needed, however 10% fatal.