Treatments > Biological > Medication > Neuroleptic Malignant Syndrome (NMS)

Neuroleptic Malignant Syndrome (NMS)

  • Idiosyncratic side effect primarily associated with antipsychotics


  • Marked by

- muscular rigidity pyrexia,

- autonomic instability (unstable BP, tachycardia, increased sweating,  increased salivation, urinary incontinence),

- decreased consciousness,

- increased creatinine kinase (CPK),

- leucocytosis,

- low serum iron


  • Medical emergency that can lead to death.


  • Treatment 

- stop neuroleptic, treat hyperthermia aggressively.

- May need ICU.

- Dopamine agonists (dantrolene), benzodiazapines for agitation.

- Aggressive hydration with diuresis as myoglobin levels may result in renal failure.


  • Early recognition needed, however 10% fatal.