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Examples: moclobemide, isocarboxazid, phenelzine, tranylcypromine.
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Mechanism of action: this inhibits monoamine oxidase, which prevents breakdown on monoamines and increased their availability in the synaptic cleft.
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Common side-effects
- Risk of hypertensive crisis - diet/medications, “cheese reaction”- prevents breakdown on tyramine.
- Anticholinergic, hepatotoxicity, insomnia, anxiety, weight gain, postural hypotension, sexual dysfunction, ankle oedema.
Treatments > Biological > Medication > Monoamine Oxidase Inhibitors (MAOIs)