Monoamine Oxidase Inhibitors (MAOIs)
Examples: moclobemide, isocarboxazid, phenelzine, tranylcypromine.
Mechanism of action: this inhibits monoamine oxidase, which prevents breakdown on monoamines and increased their availability in the synaptic cleft.
- Risk of hypertensive crisis - diet/medications, “cheese reaction”- prevents breakdown on tyramine.
- Anticholinergic, hepatotoxicity, insomnia, anxiety, weight gain, postural hypotension, sexual dysfunction, ankle oedema.