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Norepinephrine and specific serotonergic antidepressant (NaSSA).
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Common adverse effects
- Sedation, increased appetite/weight gain
- Less common: jaundice/LFT changes, postural hypotension, blood dyscrasias
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Advantages
- Sedative at low dose
- Less sexual dysfunction and GI upset
- Low toxicity in overdose
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Disadvantages
- Weight gain
- Sedative effects lost at high dose
Treatments > Biological > Medication > Mirtazepine