Treatments  > Biological > Medication > Choice Of Antipsychotic

Choice of Antipsychotic

  • NICE guidelines - first medication atypical antipsychotic, if needed change to another antipsychotic, if two trials tried and remains in need of treatment, for consideration of clozapine.

  • Clinical assessment - consider duration of untreated psychosis, risks, insight etc.

  • Consider side effect profile and tolerability.

  • Compliance; if monitoring is an issue, plasma levels, compliance aids, electronic devices, legal frameworks, MH/external services direct monitoring.

  • If compliance is an issue consider depot, ¼ to 1/3 community patients on depot.

  • If treatment resistant consider clozapine as soon as appropriate following trial of two antipsychotics at treatment doses and length, limited by tolerability and blood testing.

  • Avoid poly pharmacy with two antipsychotics, no evidence for this unless augmenting clozapine or adding aripiprazole for hyperprolactinemia.

Copyright 2012 RevisePsych

Last updated March 2020

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