RevisePsych
Undergraduate psychiatry revision
Treatments > Biological > Medication > Atypicals
Atypicals
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Amisulpride, Olanzapine, Paliperidone, Quetiapine, Risperidone, Sertindole, Sulpiride, Ziprasidone, Zotepine, Clozapine.
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Significantly lower propensity to produce EPSE and cause sustained hyperpolactinemia at clinically effective doses
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Various modes of action, cf. typicals ? D2/5HT (no longer supported).
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Less EPSEs than first generation, modestly increased efficacy with olazapine, marked increased efficacy with clozapine.
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Previously thought to be superior for negative symptoms, however research has shown that this is not the case.
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Generally - less EPSE but higher incidence of metabolic side effects than ‘typicals’ but exceptions- aripiprazole.